An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans

• Main Authors: Otto Tschritter (Author), Axel Haupt (Author), Hubert Preissl (Author), Caroline Ketterer (Author), Anita M. Hennige (Author), Tina Sartorius (Author), Fausto Machicao (Author), Andreas Fritsche (Author), Hans-Ulrich Häring (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of melanocortin-4 receptor (MC4R) by insulin sensitive neurons is a central mechanism in body weight regulation, and genetic variants in the MC4R gene (e.g., rs17782313) are associated with obesity. By using magnetoencephalography, we addressed whether rs17782313 affects the cerebrocortic...