In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9

• Main Authors: Jing Mi (Author), Partha Ray (Author), Jenny Liu (Author), Chien-Tsun Kuan (Author), Jennifer Xu (Author), David Hsu (Author), Bruce A Sullenger (Author), Rebekah R White (Author), Bryan M Clary (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an in vivo selection strategy to identify RNA aptamers...