Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes.

• Main Authors: Francesco Citiulo (Author), Francesca Necchi (Author), Francesca Mancini (Author), Omar Rossi (Author), Maria Grazia Aruta (Author), Gianmarco Gasperini (Author), Renzo Alfini (Author), Simona Rondini (Author), Francesca Micoli (Author), Rino Rappuoli (Author), Allan Saul (Author), Laura B Martin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disease. The leading Shigella vaccine strategies are based...