HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells

• Main Authors: Chien-Chung Yang (Author), Li-Der Hsiao (Author), Chen-Yu Wang (Author), Wei-Ning Lin (Author), Ya-Fang Shih (Author), Yi-Wen Chen (Author), Rou-Ling Cho (Author), Hui-Ching Tseng (Author), Chuen-Mao Yang (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung inflammation is a pivotal event in the pathogenesis of acute lung injury. Heme oxygenase-1 (HO-1) is a key antioxidant enzyme that could be induced by kaempferol (KPR) and exerts anti-inflammatory effects. However, the molecular mechanisms of KPR-mediated HO-1 expression and its effects on infl...