PPARγ Transcription Deficiency Exacerbates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance in Mice

• Main Authors: Fusheng Guo (Author), Shuangshuang Xu (Author), Yanlin Zhu (Author), Xing Zheng (Author), Yi Lu (Author), Jui Tu (Author), Ying He (Author), Lihua Jin (Author), Yong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe transcriptional factor peroxisome proliferator-activated receptor γ (PPARγ) is an important therapeutic target for the treatment of type 2 diabetes. However, the role of the PPARγ transcriptional activity remains ambiguous in its metabolic regulation.MethodsBased on the crystal structu...