Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation

• Main Authors: Xu Ying (Author), Su Yue (Author), Hu Yuwen (Author), Li Xiang (Author), Zhou Ziyan (Author), Yuan Ningning (Author), Ji Xiaowei (Author), Jiang Ruoyu (Author), Wang Wenzhu (Author), Zhang Yafeng (Author), Zhai Guojie (Author), Cheng Xiaolan (Author)
• Format: Book
• Published: Elsevier, 2025-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Paclitaxel-induced cognitive impairment (PICI) is a frequent and severe adverse reaction of chemotherapy. Increased neuroinflammation related to neutrophil extracellular traps (NETs) may play a key role in PICI. Shaoyao Gancao Decoction (SGD) is a classic Chinese prescription with good neur...