Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

• Main Authors: Vivien R. Sutton (Author), Sally V. Watt (Author), Hedieh Akhlaghi (Author), David C. Cipolla (Author), Kuan-Ju Chen (Author), Daniel LaSala (Author), Patrick P. McDonald (Author), Paul A. Beavis (Author), Isabelle Munoz (Author), Adrian W. Hodel (Author), Tahereh Noori (Author), Ilia Voskoboinik (Author), Joseph A. Trapani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of neutrophil serine proteases (NSPs), including neutrophil elast...