Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

• Main Authors: Panagiotis Kanellopoulos (Author), Adam Mattsson (Author), Ayman Abouzayed (Author), Karim Obeid (Author), Berthold A. Nock (Author), Vladimir Tolmachev (Author), Theodosia Maina (Author), Anna Orlova (Author)
• Format: Book
• Published: SpringerOpen, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rapid clearance of peptide radioligands, including radiolabeled GRPR-antagonists, often impede...