Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

• Auteurs principaux: Panagiotis Kanellopoulos (Auteur), Adam Mattsson (Auteur), Ayman Abouzayed (Auteur), Karim Obeid (Auteur), Berthold A. Nock (Auteur), Vladimir Tolmachev (Auteur), Theodosia Maina (Auteur), Anna Orlova (Auteur)
• Format: Livre
• Publié: SpringerOpen, 2024-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rapid clearance of peptide radioligands, including radiolabeled GRPR-antagonists, often impede...