Borneol and Α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors

• Main Authors: Jun-Yong Wu (Author), Yong-Jiang Li (Author), Le Yang (Author), Yi-Yun Hu (Author), Xiong-Bin Hu (Author), Tian-Tian Tang (Author), Jie-Min Wang (Author), Xin-Yi Liu (Author), Da-Xiong Xiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed...