Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides

Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen Trichomonas vaginalis encodes two such enzymes belonging to the β-class, TvaCA1 and TvaCA2. Here we report the first sulphonamide inhibition study of TvaCA1,...

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Main Authors: Linda J. Urbański (Author), Andrea Angeli (Author), Vesa P. Hytönen (Author), Anna Di Fiore (Author), Giuseppina De Simone (Author), Seppo Parkkila (Author), Claudiu T. Supuran (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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