Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides

• Asıl Yazarlar: Linda J. Urbański (Yazar), Andrea Angeli (Yazar), Vesa P. Hytönen (Yazar), Anna Di Fiore (Yazar), Giuseppina De Simone (Yazar), Seppo Parkkila (Yazar), Claudiu T. Supuran (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen Trichomonas vaginalis encodes two such enzymes belonging to the β-class, TvaCA1 and TvaCA2. Here we report the first sulphonamide inhibition study of TvaCA1,...