FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

• Main Authors: Yun-Kyoung Lee (Author), Bryan Diaz (Author), Marianne Deroose (Author), Samuel X. Lee (Author), Sandro Belvedere (Author), Domenico Accili (Author), Rudolph L. Leibel (Author), Hua V. Lin (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Forkhead box protein O1 (FOXO1) plays a key role in regulating hepatic glucose production, but investigations of FOXO1 inhibition as a potential therapeutic approach have been hampered by a lack of selective chemical inhibitors. By profiling structurally diverse FOXO1 inhibitors, the curr...