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Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) <sup>18</sup>F-Radiopharmaceuticals

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of <sup>18</sup>F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiof...

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Main Authors: Lexi Gower-Fry (Author), Travis Kronemann (Author), Andreas Dorian (Author), Yinglan Pu (Author), Carolin Jaworski (Author), Carmen Wängler (Author), Peter Bartenstein (Author), Leonie Beyer (Author), Simon Lindner (Author), Klaus Jurkschat (Author), Björn Wängler (Author), Justin J. Bailey (Author), Ralf Schirrmacher (Author)
Format: Book
Published: MDPI AG, 2021-07-01T00:00:00Z.
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Summary:The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of <sup>18</sup>F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [<sup>18</sup>F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [<sup>18</sup>F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.
Item Description:10.3390/ph14070701
1424-8247

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