Structure-Based Virtual Screening of Furan-1,3,4-Oxadiazole Tethered <i>N</i>-phenylacetamide Derivatives as Novel Class of hTYR and hTYRP1 Inhibitors

• Main Authors: Ali Irfan (Author), Shah Faisal (Author), Sajjad Ahmad (Author), Sami A. Al-Hussain (Author), Sadia Javed (Author), Ameer Fawad Zahoor (Author), Bushra Parveen (Author), Magdi E. A. Zaki (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human tyrosinase (hTYR) is a key and rate-limiting enzyme along with human tyrosinase-related protein-1 (hTYRP1), which are among the most prominent targets of inhibiting hyper pigmentation and melanoma skin cancer. In the current in-silico computer-aided drug design (CADD) study, the structure-base...