Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

• Main Authors: Viktoria Stachanow (Author), Uta Neumann (Author), Oliver Blankenstein (Author), Davide Bindellini (Author), Johanna Melin (Author), Richard Ross (Author), Martin J. Whitaker (Author), Wilhelm Huisinga (Author), Robin Michelet (Author), Charlotte Kloft (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Congenital adrenal hyperplasia (CAH) is the most common form of adrenal insufficiency in childhood; it requires cortisol replacement therapy with hydrocortisone (HC, synthetic cortisol) from birth and therapy monitoring for successful treatment. In children, the less invasive dried blood spot (DBS)...