Resistance to PARP-inhibitors in Cancer Therapy

• Main Authors: Alicia eMontoni (Author), Mihaela eRobu (Author), Emilie ePouliot (Author), Girish M. Shah (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2013-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) family of proteins have shown promising results in preclinical studies and clinical trials as a monotherapy or in combination therapy for some cancers. Thus, usage of PARP-inhibitors (PARPi) in cancer therapy is bound to increase w...