Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation

• Main Authors: Michele De Luca (Author), Maria Antonietta Occhiuzzi (Author), Bruno Rizzuti (Author), Giuseppina Ioele (Author), Gaetano Ragno (Author), Antonio Garofalo (Author), Fedora Grande (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Letrozole is one of the most prescribed drugs for the treatment of breast cancer in post-menopausal women, and it is endowed with selective peripheral aromatase inhibitory activity. The efficacy of this drug is also a consequence of its long-lasting activity, likely due to its metabolic stability. T...