Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

• 主要な著者: Giulia Zanetti (著者), Andrea Mattarei (著者), Florigio Lista (著者), Ornella Rossetto (著者), Cesare Montecucco (著者), Marco Pirazzini (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Tetanus neurotoxin (TeNT) is a protein exotoxin produced by <i>Clostridium tetani</i> that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond. TeNT binds to the neuromuscular junction (NMJ) a...