Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

• Main Authors: Giulia Zanetti (Author), Andrea Mattarei (Author), Florigio Lista (Author), Ornella Rossetto (Author), Cesare Montecucco (Author), Marco Pirazzini (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetanus neurotoxin (TeNT) is a protein exotoxin produced by <i>Clostridium tetani</i> that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond. TeNT binds to the neuromuscular junction (NMJ) a...