Cover Image

Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

Tetanus neurotoxin (TeNT) is a protein exotoxin produced by <i>Clostridium tetani</i> that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond. TeNT binds to the neuromuscular junction (NMJ) a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Giulia Zanetti (Author), Andrea Mattarei (Author), Florigio Lista (Author), Ornella Rossetto (Author), Cesare Montecucco (Author), Marco Pirazzini (Author)
Format:	Book
Published:	MDPI AG, 2021-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomation.
by: Marco Stazi, et al.
Published: (2020)

Agonists of melatonin receptors strongly promote the functional recovery from the neuroparalysis induced by neurotoxic snakes.
by: Giorgia D'Este, et al.
Published: (2024)

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
by: Edanur Sen, et al.
Published: (2021)

Intramuscular tetanus neurotoxin reverses muscle atrophy: a randomized controlled trial in dogs with spinal cord injury
by: Anna Kutschenko, et al.
Published: (2022)

Neurotoxins
Published: (2018)

Small Molecule Inhibitors of CRM1
by: Bibiana I. Ferreira, et al.
Published: (2020)

A novel small-molecule inhibitor of HIV-1 entry
by: Heredia A, et al.
Published: (2015)

Small Molecule Inhibitors of Influenza Virus Entry
by: Zhaoyu Chen, et al.
Published: (2021)

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
by: Yanan Liu, et al.
Published: (2021)

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
by: Mazen Aseeri, et al.
Published: (2023)

Extended Applications of Small-Molecule Covalent Inhibitors toward Novel Therapeutic Targets
by: Jesang Lee, et al.
Published: (2022)

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
by: Tony Eight Lin, et al.
Published: (2022)

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics
by: Chris Chun-Yiu Chan, et al.
Published: (2024)

Small molecule KDM4s inhibitors as anti-cancer agents
by: Hongzhi Lin, et al.
Published: (2018)

Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment
by: Xiaohang Zheng, et al.
Published: (2022)

Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy
by: Wenjing Xiao, et al.
Published: (2021)

Recent Research Advances in Small-Molecule Pan-PIM Inhibitors
by: Lei Xu, et al.
Published: (2022)

Impact of Selected Small-Molecule Kinase Inhibitors on Lipid Membranes
by: Meike Luck, et al.
Published: (2021)

A mini review of small-molecule inhibitors targeting palmitoyltransferases
by: Xiaotong Hu, et al.
Published: (2022)

Botulinum neurotoxin formulations: overcoming the confusion
by: Samizadeh S, et al.
Published: (2018)

Small molecule inhibitors target multiple neuropathological signaling to exert novel neuroprotection in intracranial aneurysms
by: Acharya Balkrishna, et al.
Published: (2024)

Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy
by: Aisha Alsfouk
Published: (2021)

Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma
by: Jie Yi Tan, et al.
Published: (2023)

A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic Reticulum Stress
by: Daniela Correia da Silva, et al.
Published: (2022)

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase
by: Supreet Kaur, et al.
Published: (2022)

Small molecules, inhibitors of DNA-PK, targeting DNA repair and beyond
by: David eDavidson, et al.
Published: (2013)

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792
by: Masako Sasaki, et al.
Published: (2019)

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone
by: Fernanda A. H. Batista, et al.
Published: (2020)

Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
by: Charles J. Malemud
Published: (2010)

Recent progress of small-molecule of RET inhibitors against Non-small cell lung cancer
by: Jiayi Shen, et al.
Published: (2024)

Botulinum Neurotoxins and Nervous System Future Challenges for Novel Indications
Published: (2020)

Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma
by: Chang-Keun Kim
Published: (2013)

Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy
by: Qi Liu, et al.
Published: (2023)

Recent Progress in the Development of Small-Molecule FtsZ Inhibitors as Chemical Tools for the Development of Novel Antibiotics
by: Laura Carro
Published: (2019)

Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1
by: Anja Kolarič, et al.
Published: (2022)

Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a
by: Yueling Zhong, et al.
Published: (2019)

Botulinum neurotoxin formulations: overcoming the confusion [Corrigendum]
by: Samizadeh S, et al.
Published: (2018)

Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains
by: Stephen eToth, et al.
Published: (2012)

Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors
by: Prakash Arullampalam, et al.
Published: (2021)

Structure–activity exploration of a small-molecule Lipid II inhibitor
by: Fletcher S, et al.
Published: (2015)