Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability

• मुख्य लेखकों: Muhammad Ajaz Hussain (लेखक), Iqra Shad (लेखक), Iram Malik (लेखक), Fasiha Amjad (लेखक), Tehreem Kausar (लेखक), Kamran (लेखक), Muhammad Sher (लेखक), Muhammad Nawaz Tahir (लेखक), Nisar Ullah (लेखक), Muhammad Ashraf (लेखक), Syed Nasir Abbas Bukhari (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Herein, we report novel macromolecular prodrugs (MPDs) of flurbiprofen (FLB) onto a cellulose ether, hydroxypropylcellulose (HPC). The FLB was activated with a powerful acylation reagent carbonyldiimadazole (CDI) in N,N' dimethylacetamide (DMAc) solvent at room temperature. Imidazolide of FLB g...