Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability

Herein, we report novel macromolecular prodrugs (MPDs) of flurbiprofen (FLB) onto a cellulose ether, hydroxypropylcellulose (HPC). The FLB was activated with a powerful acylation reagent carbonyldiimadazole (CDI) in N,N' dimethylacetamide (DMAc) solvent at room temperature. Imidazolide of FLB g...

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Main Authors: Muhammad Ajaz Hussain (Author), Iqra Shad (Author), Iram Malik (Author), Fasiha Amjad (Author), Tehreem Kausar (Author), Kamran (Author), Muhammad Sher (Author), Muhammad Nawaz Tahir (Author), Nisar Ullah (Author), Muhammad Ashraf (Author), Syed Nasir Abbas Bukhari (Author)
Format: Book
Published: Elsevier, 2020-07-01T00:00:00Z.
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