Cross-comparison of exome analysis, next-generation sequencing of amplicons, and the iPLEX® ADME PGx Panel for pharmacogenomic profiling

• Glavni autori: Eng Wee eChua (Autor), Martin A Kennedy (Autor), Simone L Cree (Autor), Kim N. T. Ton (Autor), Klaus eLehnert (Autor), Phillip eShepherd (Autor), Nuala eHelsby (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2016-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Whole-exome sequencing (WES) has been widely used for analysis of human genetic diseases, but its value for the pharmacogenomic profiling of individuals is not well studied. Initially, we performed an in-depth evaluation of the accuracy of WES variant calling in the pharmacogenes CYP2D6 and CYP2C19...