Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping

• Main Authors: Masataka Kikuchi (Author), Norikazu Hara (Author), Mai Hasegawa (Author), Akinori Miyashita (Author), Ryozo Kuwano (Author), Takeshi Ikeuchi (Author), Akihiro Nakaya (Author)
• Formato: Livro
• Publicado em: BMC, 2019-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) that may be genetic factors underlying Alzheimer's disease (AD). However, how these AD-associated SNPs (AD SNPs) contribute to the pathogenesis of this disease is poorly understood...