Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping

• Автори: Masataka Kikuchi (Автор), Norikazu Hara (Автор), Mai Hasegawa (Автор), Akinori Miyashita (Автор), Ryozo Kuwano (Автор), Takeshi Ikeuchi (Автор), Akihiro Nakaya (Автор)
• Формат: Книга
• Опубліковано: BMC, 2019-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) that may be genetic factors underlying Alzheimer's disease (AD). However, how these AD-associated SNPs (AD SNPs) contribute to the pathogenesis of this disease is poorly understood...