Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

• Main Authors: Astrid L. Basse (Author), Marianne Agerholm (Author), Jean Farup (Author), Emilie Dalbram (Author), Joachim Nielsen (Author), Niels Ørtenblad (Author), Ali Altıntaş (Author), Amy M. Ehrlich (Author), Thomas Krag (Author), Santina Bruzzone (Author), Morten Dall (Author), Roldan M. de Guia (Author), Jonas B. Jensen (Author), Andreas B. Møller (Author), Anders Karlsen (Author), Michael Kjær (Author), Romain Barrès (Author), John Vissing (Author), Steen Larsen (Author), Niels Jessen (Author), Jonas T. Treebak (Author)
• Format: Bog
• Udgivet: Elsevier, 2021-11-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Objective: NAD+ is a co-factor and substrate for enzymes maintaining energy homeostasis. Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD+ synthesis, and in skeletal muscle, NAD+ is essential for muscle integrity. However, the underlying molecular mechanisms by which NAD+ synthesis affect...