Distinct non-clock-like signatures of the basal cell carcinomas from three sisters with a lethal Gorlin-Goltz syndrome

• Main Authors: Lihua Ye (Author), Li Wang (Author), Kexin Peng (Author), Ou Fang (Author), Zhen Tian (Author), Caihua Li (Author), Xiaopeng Fu (Author), Qingdong Chen (Author), Jia Chen (Author), Jing Luan (Author), Zhenghua Zhang (Author), Qiaoan Zhang (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Gorlin-Goltz syndrome (GS) is an inherited disease characterized by predisposition to basal cell carcinomas (BCCs) and various developmental defects, whose numerous disease-causing PTCH1 mutations have been identified in the hedgehog (Hh) signaling pathway. Methods In this study,...