Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

• Main Authors: Javad Garousi (Author), Haozhong Ding (Author), Emma von Witting (Author), Tianqi Xu (Author), Anzhelika Vorobyeva (Author), Maryam Oroujeni (Author), Anna Orlova (Author), Sophia Hober (Author), Torbjörn Gräslund (Author), Vladimir Tolmachev (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Albumin binding domain derived affinity proteins (ADAPTs) are a class of small and folded engineered scaffold proteins that holds great promise for targeting cancer tumors. Here, we have extended the in vivo half-life of an ADAPT, targeting the human epidermal growth factor receptor 2 (HER2) by fusi...