Implications of the RhoA/Rho associated kinase pathway and leptin in primary uterine inertia in the dog

• Main Authors: Bianca Lourdes FREHNER (Author), Iris Margaret REICHLER (Author), Mariusz Pawel KOWALEWSKI (Author), Aykut GRAM (Author), Stefanie KELLER (Author), Sandra GOERICKE-PESCH (Author), Orsolya BALOGH (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The underlying functional and molecular changes in canine primary uterine inertia (PUI) are still not clarified. Leptin (Lep) and obesity negatively affect uterine contractility in women, partly mediated by the RhoA/Rho associated kinase pathway, affecting myometrial calcium sensitization. We hypoth...