Osteolytic Bone Loss and Skeletal Deformities in a Mouse Model for Early-Onset Paget's Disease of Bone with <i>PFN1</i> Mutation Are Treatable by Alendronate

• Main Authors: Zhu Ling (Author), Hailati Aini (Author), Shuhei Kajikawa (Author), Jumpei Shirakawa (Author), Kunikazu Tsuji (Author), Yoshinori Asou (Author), Hideyuki Koga (Author), Ichiro Sekiya (Author), Akira Nifuji (Author), Masaki Noda (Author), Yoichi Ezura (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel osteolytic disorder due to <i>PFN1</i> mutation was discovered recently as early-onset Paget's disease of bone (PDB). Bone loss and pain in adult PDB patients have been treated using bisphosphonates. However, therapeutic strategies for this specific disorder have not been es...