Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2.

• Главные авторы: Jorge Andrés Castillo (Автор), Diana M Giraldo (Автор), Juan C Hernandez (Автор), Jolanda M Smit (Автор), Izabela A Rodenhuis-Zybert (Автор), Silvio Urcuqui-Inchima (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2021-10-01T00:00:00Z.
• Предметы: article
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A dysregulated or exacerbated inflammatory response is thought to be the key driver of the pathogenesis of severe disease caused by the mosquito-borne dengue virus (DENV). Compounds that restrict virus replication and modulate the inflammatory response could thus serve as promising therapeutics miti...