Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2.

• Main Authors: Jorge Andrés Castillo (Author), Diana M Giraldo (Author), Juan C Hernandez (Author), Jolanda M Smit (Author), Izabela A Rodenhuis-Zybert (Author), Silvio Urcuqui-Inchima (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A dysregulated or exacerbated inflammatory response is thought to be the key driver of the pathogenesis of severe disease caused by the mosquito-borne dengue virus (DENV). Compounds that restrict virus replication and modulate the inflammatory response could thus serve as promising therapeutics miti...