IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

• Main Authors: Yuto Otsuka (Author), Takao Kondo (Author), Hiromasa Aoki (Author), Yoh Goto (Author), Yohei Kawaguchi (Author), Yuko Waguri-Nagaya (Author), Ken Miyazawa (Author), Shigemi Goto (Author), Mineyoshi Aoyama (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone remodeling mediated by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCs) maintains bone structure and function. Excessive OC activation leads to bone-destroying diseases such as osteoporosis and bone erosion of rheumatoid arthritis (RA). Differentiation of OCs from bone marrow...