IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

• Главные авторы: Yuto Otsuka (Автор), Takao Kondo (Автор), Hiromasa Aoki (Автор), Yoh Goto (Автор), Yohei Kawaguchi (Автор), Yuko Waguri-Nagaya (Автор), Ken Miyazawa (Автор), Shigemi Goto (Автор), Mineyoshi Aoyama (Автор)
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• Опубликовано: Elsevier, 2023-01-01T00:00:00Z.
• Предметы: article
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Bone remodeling mediated by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCs) maintains bone structure and function. Excessive OC activation leads to bone-destroying diseases such as osteoporosis and bone erosion of rheumatoid arthritis (RA). Differentiation of OCs from bone marrow...