Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

• Main Authors: Chih-Ming Tsai (Author), Angelica M. Riestra (Author), Syed Raza Ali (Author), Jerry J. Fong (Author), Janet Z. Liu (Author), Gillian Hughes (Author), Ajit Varki (Author), Victor Nizet (Author)
• Format: Book
• Published: Karger Publishers, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired sialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have recipr...