Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes.

• Үндсэн зохиолчид: Simon A Babayan (Зохиогч), Honglin Luo (Зохиогч), Nick Gray (Зохиогч), David W Taylor (Зохиогч), Judith E Allen (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on its capacit...