Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat β-Cell Line RIN-5F

Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat β-Cell Line RIN-5F

Abstract.: Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F. We examined the effect of extracellular-added ADP-ribose on intracellular Ca2+ concentration in RIN-5F cells. ADP-ribo...

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Main Authors: Ishii Masakazu (Author), Shimizu Shunichi (Author), Hagiwara Tamio (Author), Wajima Teruaki (Author), Miyazaki Akira (Author), Mori Yasuo (Author), Kiuchi Yuji (Author)
Format: Book
Published: Elsevier, 2006-01-01T00:00:00Z.
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