The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models

• Main Authors: Nils Bögeholz (Author), Jan S. Schulte (Author), Sven Kaese (Author), B. Klemens Bauer (Author), Paul Pauls (Author), Dirk G. Dechering (Author), Gerrit Frommeyer (Author), Joshua I. Goldhaber (Author), Uwe Kirchhefer (Author), Lars Eckardt (Author), Christian Pott (Author), Frank U. Müller (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objective: The cardiac Na+/Ca2+ exchanger (NCX) has been identified as a promising target to counter arrhythmia in previous studies investigating the benefit of NCX inhibition. However, the consequences of NCX inhibition have not been investigated in the setting of altered NCX expression...