Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

• Main Authors: Yang Tong (Author), Pei An (Author), Puxian Tang (Author), Rui Mu (Author), Yuteng Zeng (Author), Hang Sun (Author), Mei Zhao (Author), Ziyan Lv (Author), Pan Wang (Author), Wanjun Han (Author), Chunshan Gui (Author), Xuechu Zhen (Author), Liang Han (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments. Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood‒tumor barrier (BTB). BTB activates its Wnt signaling to main...