Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway

• Main Authors: Minjun Yao (Author), Caihua Zhang (Author), Lingzhi Ni (Author), Xiaoxiao Ji (Author), Jianqiao Hong (Author), Yazhou Chen (Author), Jie Wang (Author), Congsun Li (Author), Jiyan Lin (Author), Tingting Lu (Author), Yihao Sheng (Author), Menghao Sun (Author), Mingmin Shi (Author), Chenhe Zhou (Author), Xunzi Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from the plant Stephania cepha...