Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity

• Päätekijät: Mohamed F. Zaky (Tekijä), Mohamed A. Megahed (Tekijä), Taha M. Hammady (Tekijä), Shadeed Gad (Tekijä), Mamdouh Mostafa Ghorab (Tekijä), Khalid M. El-Say (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of an Apx-loaded nanostructured lipid carrier (NLC) to...