Aptamer-Functionalized Nanoparticles Mediate PD-L1 siRNA Delivery for Effective Gene Silencing in Triple-Negative Breast Cancer Cells

• Main Authors: Simona Camorani (Author), Silvia Tortorella (Author), Lisa Agnello (Author), Chiara Spanu (Author), Annachiara d'Argenio (Author), Roberto Nilo (Author), Antonella Zannetti (Author), Erica Locatelli (Author), Monica Fedele (Author), Mauro Comes Franchini (Author), Laura Cerchia (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNA (siRNA) therapies require effective delivery vehicles capable of carrying the siRNA cargo into target cells. To achieve tumor-targeting, a drug delivery system would have to incorporate ligands that specifically bind to receptors expressed on cancer cells to function as portals...