Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease

• 主要な著者: Xiaoying Jiang (著者), Jianan Guo (著者), Changjun Zhang (著者), Jinping Gu (著者), Tao Zhou (著者), Renren Bai (著者), Yuanyuan Xie (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged approaches based on lead compounds 18d, benzyloxy...