A Novel Small-Molecule Inhibitor of SREBP-1 Based on Natural Product Monomers Upregulates the Sensitivity of Lung Squamous Cell Carcinoma Cells to Antitumor Drugs

• Main Authors: De-Bin Ma (Author), Xing-Yu Liu (Author), Hui Jia (Author), Yingshi Zhang (Author), Qiyu Jiang (Author), Huiwei Sun (Author), Xiaojuan Li (Author), Fang Sun (Author), Yantao Chai (Author), Fan Feng (Author), Lei Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transcription factor, sterol regulatory element binding protein 1 (SREBP-1), plays important roles in modulating the proliferation, metastasis, or resistance to antitumor agents by promoting cellular lipid metabolism and related cellular glucose-uptake/Warburg Effect. However, the underlying mec...