Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

• Main Authors: Maria Dehli Vigeland (Author), Siri Tennebø Flåm (Author), Magnus Dehli Vigeland (Author), Ansgar Espeland (Author), Manuela Zucknick (Author), Monica Wigemyr (Author), Lars Christian Haugli Bråten (Author), Elisabeth Gjefsen (Author), John-Anker Zwart (Author), Kjersti Storheim (Author), Linda Margareth Pedersen (Author), Kaja Selmer (Author), Benedicte Alexandra Lie (Author), Kristina Gervin (Author), The AIM Study Group (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (<i>n</i> = 100) receiving amoxicil...