Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

• Autores principales: Maria Dehli Vigeland (Autor), Siri Tennebø Flåm (Autor), Magnus Dehli Vigeland (Autor), Ansgar Espeland (Autor), Manuela Zucknick (Autor), Monica Wigemyr (Autor), Lars Christian Haugli Bråten (Autor), Elisabeth Gjefsen (Autor), John-Anker Zwart (Autor), Kjersti Storheim (Autor), Linda Margareth Pedersen (Autor), Kaja Selmer (Autor), Benedicte Alexandra Lie (Autor), Kristina Gervin (Autor), The AIM Study Group (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (<i>n</i> = 100) receiving amoxicil...