Pregnenolone Biosynthesis in the Rat Salivary Gland and Its Inhibitory Effect on Secretion

• Main Authors: Takashi Miyashita (Author), Migiwa Okubo (Author), Takashi Shinomiya (Author), Kan-Ichi Nakagawa (Author), Mitsuru Kawaguchi (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnenolone (PRG), a major neurosteroid, suppressed carbachol-induced salivary secretion in perfused submandibular gland in rats. These effects were enhanced and depressed by agonistic muscimol (MUS) and antagonistic bicuculline to the γ-aminobutyric acid A receptor (GABAA-R), respectively. In cont...