Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

• Main Authors: Hales Tim G (Author), Maidment Nigel T (Author), Evans Christopher J (Author), Pradhan Amynah (Author), Maga Matthew (Author), Lam Hoa (Author), Walwyn Wendy (Author)
• Format: Book
• Published: SAGE Publishing, 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Hedonic reward, dependence and addiction are unwanted effects of opioid analgesics, linked to the phasic cycle of μ opioid receptor activation, tolerance and withdrawal. <it>In vitro </it>studies of recombinant G protein coupled receptors (GPCRs) over...