Exceeding the guideline-recommended maximum daily dose of opioids for long-term treatment of non-cancer pain in Germany - a large retrospective observational study

• Main Authors: Nils Frederik Schrader (Author), Anja Niemann (Author), Milena Weitzel (Author), Christian Speckemeier (Author), Carina Abels (Author), Nikola Blase (Author), Godwin Denk Giebel (Author), Cordula Riederer (Author), Joachim Nadstawek (Author), Wolfgang Straßmeir (Author), Jürgen Wasem (Author), Silke Neusser (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High-dose long-term opioid therapy (LTOT) has been associated with increased mortality and hospitalizations. Therefore, the evidence-based German guideline on LTOT for chronic non-cancer pain (CNCP) recommends to only exceed the maximum daily dose (MDD) of opioids in exceptional...