Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

• Main Authors: Ali R. Banijamali (Author), Andrew E. Carvalho (Author), James D. Wakefield (Author), Peter Germano (Author), Timothy C. Barden (Author), Jenny V. Tobin (Author), Daniel P. Zimmer (Author), Jaime L. Masferrer (Author), Albert T. Profy (Author), Mark G. Currie (Author), G. Todd Milne (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA) study conducted in male Long‐Evans rats....