Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

• Main Authors: B Divyakant Patel (Author), R Valay Modi (Author), N Alok Thakkar (Author), A Arpita Patel (Author), P Hetal Thakkar (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to increase the oral bioavailability of Raloxifene having an absolute bioavailability only 2% due to extensive first pass hepatic metabolism by incorporating it in Solid Lipid Nanoparticles (SLNs). The optimized RSLNs prepared by Ultrasonic Emulsification and Low Temp...