Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene

• Váldodahkkit: B Divyakant Patel (Dahkki), R Valay Modi (Dahkki), N Alok Thakkar (Dahkki), A Arpita Patel (Dahkki), P Hetal Thakkar (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The objective of this study was to increase the oral bioavailability of Raloxifene having an absolute bioavailability only 2% due to extensive first pass hepatic metabolism by incorporating it in Solid Lipid Nanoparticles (SLNs). The optimized RSLNs prepared by Ultrasonic Emulsification and Low Temp...