TLR1/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T Cell responses providing protection against Leishmania (Viannia).

• Main Authors: Asha Jayakumar (Author), Tiago M Castilho (Author), Esther Park (Author), Karen Goldsmith-Pestana (Author), Jenefer M Blackwell (Author), Diane McMahon-Pratt (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species, indicating a unique interaction with the host. Further, vaccination studies utilizing small animal models indicate that modalities and antigens...