Effects of urotensin II receptor antagonist, GSK1440115, in asthma

• Main Authors: Alison D Portnoy (Author), Sanjay eKumar (Author), David J Behm (Author), Kelly M Mahr (Author), Robert B Noble (Author), John eThroup (Author), Steven F Russ (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Urotensin II (U-II) is highly expressed in the human lung and has been implicated in regulating respiratory physiology in preclinical studies. Our objective was to test antagonism of the urotensin receptor (UT) by GSK1440115, a novel, competitive and selective inhibitor of the UT recepto...