Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants

• Main Authors: Orestis Papasouliotis (Author), David Mitchell (Author), Pascal Girard (Author), Martin Dyroff (Author)
• Formato: Livro
• Publicado em: Wiley, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Evobrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, has shown therapeutic potential in relapsing multiple sclerosis. This analysis aimed to develop pharmacokinetic (PK) and pharmacodynamic (PD; BTK occupancy [BTKO]) models of evobrutinib and simulate PK and BTKO profiles under alt...