Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLCâMS/MS and its application to a pharmacokinetic study

• Main Authors: Xiao-Hong Zheng (Author), Li-Yuan Jiang (Author), Lan-Ting Zhao (Author), Quan-Ying Zhang (Author), Li Ding (Author)
• Format: Book
• Published: Elsevier, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A sensitive method based on high-performance liquid chromatographyâtandem mass spectrometry (LCâMS/MS) has been developed for the simultaneous determination of folic acid (FA) and its active metabolite, 5-methyltetrahydrofolic acid (5-M-THF), in human plasma. The analytes were extracted from plasma...