Effect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activity

• Main Authors: Masahiro Sasaki (Author), Masayuki Kashima (Author), Takefumi Ito (Author), Akiko Watanabe (Author), Masaaki Sano (Author), Manabu Kagaya (Author), Takanobu Shioya (Author), Mamoru Miura (Author)
• Format: Book
• Published: Hindawi Limited, 2000-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblast migration, proliferation, extacellular matrix protein synthesis and degradation are the key events in various biological and pathological processes in pulmonary fibrosis. In addition, biopsy specimens from the lungs of patients with plumomary fibrosis show increased numbers of mast cells...